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A separate genetic strategy expressed Gqcoupled designer receptors exclusively activated by designer drugs (DREADD) under the control of the Insl5 promoter, to allow chemogenetic stimulation of colonic Lcells (Lewis et al., 2020)

Based on current clinical evidence, Mounjaro (tirzepatide) is generally the best tolerated of the available options, with lower rates of nausea compared to semaglutide at equivalent weight loss doses

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However, for GLP-1 RAs, the adverse effects linked specifically for smoking along with long-term abstinence data are not clearly characterized, warranting further research

Phung OJ, Baker WL, Matthews LJ, Lanosa M, Thorne A, et al

Nicotinamide phosphoribosyltransferase in smooth muscle cells maintains genome integrity, resists aortic medial degeneration, and is suppressed in human thoracic aortic aneurysm disease