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In contrast, an unhealthy metabolism can present as insulin resistance or type 2 diabetes
on the use of AOM for the treatment of obesity in adolescents, top dose phentermine and topiramate as an adjunct to lifestyle counseling was estimated to be cost effective after 5 years [209]

Third, given the relatively recent introduction of GLP-1 RAs as antidiabetic treatments, the median follow-up duration in this study may have been too brief to adequately assess the long-term risk of cancer development

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[DOI] [PMC free article] [PubMed] [Google Scholar] 107

The very good reason for that is its action on irritable bowel syndrome (IBS)