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In terms of glycemic control, GLP-1RAs reduce HbA1c by approximately 1.1% to 1.6%, compared to reductions of 0.6% to 1.1% observed with DPP-4is [59]

Where semaglutide commonly ranges from 2.5-5 mg/mL, tirzepatide concentrations often reach 30-60 mg/mL

This suggests that ChREBP and downstream associated transcription factors might also play a role in the observed metabolic shift

Like all medications, GLP-1s come with potential side effects

Insurance coverage may also influence the selection of a GLP-1 agonist, as different plans may cover different drugs

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