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Compounded semaglutide bills at $299/mo as an injection or as oral tablets, and compounded tirzepatide bills at $399/mo as an injection

All GLP-1 RAs other than Saxenda and Wegovy have the indication of T2DM and are subsidized only for patients with T2DM who first tried metformin, sulphonylureas or insulin, or where these are not appropriate

In 1987, scientists discovered glucagon-like peptide 1 (GLP-1) that affects glucose metabolism

Notably, these effects were not mimicked by E alone, which failed to rescue cycle perturbations and had a discernible uterotrophic action, but were replicated, in terms of reversal of irregularities of the ovarian cycle, by GLP1 alone, which nonetheless did not elevate LH levels

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Previous analyses have suggested a larger benefit of SGLT-2 inhibitors, as compared with GLP-1RA, on cardiorenal events