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4.9 Effects on general anaesthesia One of the major concerning side effects of GLP-1RA use in anesthesia are the complications of the GI tract presenting as delayed gastric emptying and elevated gastric residual content along with other symptoms (nausea, vomiting, abdominal distension and dyspepsia) (106)

While GLP-1 receptor agonists have revolutionized the way we approach weight loss and diabetes management, their impact goes far beyond a number on the scale

It's essential to educate patients on the proper dosing and administration techniques for Ozempic, including injection site rotation, proper needle disposal, and storage requirements

They also reduce cardiovascular disease risk, as seen with semaglutide and liraglutide

Indeed, a phase 2 mechanistic trial (NCT05936151) investigating change in eGFR from baseline to week 24 with multiple doses of retatrutide vs

Fourthly, GLP-1 protects cardiomyocytes from oxidative stress and apoptosis in diabetes mellitus, through the mTOR complex1/p70 ribosomal protein S6 kinase (p70S6K) pathway [160]