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In this study, semaglutide notably increased the presence of astrocytes in cerebral blood vessels and reversed the decreased number of capillaries, as well as the leakage of IgG into the brain tissue in the cortex in the HFD SAL group (Supplementary Fig

A 20 percent LDL reduction from a weight-loss-oriented triple agonist is therefore a genuinely new observation and helps explain why retatrutide is being developed across cardiovascular, metabolic, and weight-related indications rather than as a pure obesity asset

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