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At the same time, ICER did not consider Wegovy cost-effective at the current U.S

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This shift in perspective has led to a change in the focus of research toward populations in the prodromal or preclinical stage with positive results for diagnostic biomarkers

The reason for gradual dose escalation centers on gastrointestinal adaptation and medication tolerance

Common gastrointestinal side effects include nausea (44% of patients), constipation (24%), and delayed gastric emptying, which may affect popcorn tolerance

Although we did not observe invasion of blood vessels, enhanced -SMA expression could also imply ensuing vascularization as -SMA is also an early marker of vascular smooth muscle cell maturation 67