diabetes management algorithm step 2 medicine shelf glyburide semaglutide 2·4 mg once a week in adults with overweight or obesity, and type (STEP 2): a randomised, double-blind, double-dummy, placebo-controlled, phase 3 trial Evolution of type 2 diabetes
Description
It tells your pancreas to release insulin, which helps control blood sugar

Glucagon-like peptide 1 (GLP-1) drives postprandial hyperinsulinemic hypoglycemia in pregnant women with a history of Roux-en-Y gastric bypass operation
Sienkiewicz, E

This interaction is mechanistic but manageable with low-dose initiation and dietary adjustments

Consistent with systemic exendin-4 dose-response studies, the dose of intra-VTA exendin-4 (0.05 g) used in these studies reduced cocaine seeking and did not affect ad libitum chow intake or promote malaise-like effects in rats [67, 110, 131]

A newer form of semaglutide (Rybelsus) is available as a daily tablet, but is not yet available in SA