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These effects are typically dose-dependent and tend to diminish over time, but may contribute to treatment discontinuation in a subset of patients

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doi: 10.1111/imj.16126

72 Our team used palmitic acid stimulation to induce neuronal IR, confirming that ER stress is involved in the functional damage of neurons induced by IR, and exendin significantly alleviates both ER stress and neuronal damage (data not shown)

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Research has also shown that it is not uncommon for patients to regain the weight after stopping treatment.