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Development of a ligand-based proximity labeling strategy enables interrogation of the native cell membrane interactome for the GLP-1 receptor in two cell types, revealing new regulators of receptor-mediated signaling and cell responses.

The article explores how medications like semaglutide and tirzepatide, originally approved for diabetes and obesity, are increasingly being prescribed off-label to address underlying metabolic issues such as insulin resistance, weight gain, and hormonal []