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GLP-3 might fit into combination strategies by providing complementary metabolic effects not fully achieved by GLP-1 alone, potentially enhancing specific aspects like fat oxidation or metabolic flexibility, possibly allowing lower doses of each peptide with fewer side effects, or addressing metabolic resistance that can develop with single-peptide approaches

doi: 10.1038/s12276-021-00670-3

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Recommendation: Start b12 supplementation immediately, independent of semaglutide use

Monitoring and Adjustment Self-monitoring Patients should closely monitor their physical reactions, such as blood sugar levels and gastrointestinal symptoms