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Retatrutide is the first triple-agonist peptide targeting GLP-1, GIP, and glucagon receptors simultaneously

Flier, for being an important part of the early discovery work, almost four decades ago.

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Treatment with oxyntomodulin, exendin-4 and GLP-1 increased neurite length in cultured neurons compared with controls, but did not stimulate calcium influx directly, or affect capsaicin responses
