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Intention-to-treat analyses (mean follow-up: 970 days for SGLT-2i users and 992 days for GLP-1RA users) resulted in an HR of 1.36 (95% CI 0.51, 3.61)

How GLP-1 Drugs Act Directly on Testicular Tissue The metabolic mechanism above is indirect benefits mediated through weight loss and restored hormonal signaling

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Risk of esophageal and gastric cancer in patients with type 2 diabetes receiving glucagon-like peptide-1 receptor agonists (GLP-1 RAs): a national analysis

A Phase 2 trial conducted on obese patients showed that retatrutide produced weight loss of 24.2% after 48 weeks, a result that approaches outcomes seen with bariatric surgery [55]