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In patients receiving SEM as the third-line therapy (add-on to MET + TZD or MET + SU), treatment with either dose of SEM for 30 weeks to 56 weeks was associated with greater glycemic control, compared with SIT, EXE, or IG (Table 20)

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Fayemi AO, Shifting Focus From Glycemic Statsus to Insulin Homeostasis

You should also seek advice promptly if you experience ongoing vomiting or diarrhoea, as this can lead to dehydration and may affect kidney function in some patients