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And in four major markets Canada, India, China, and Brazil semaglutides core patent either lapsed or is expiring in early 2026

OAD oral antidiabetics Systematic Reviews and Meta-analyses Four meta-analyses analyzed the metabolic outcomes of the combined therapy

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[DOI] [PMC free article] [PubMed] [Google Scholar] 31.Brubaker P.L., Drucker D.J

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The proposed mechanism involves these bacteria producing metabolitessuch as short-chain fatty acids (SCFAs)that interact with enteroendocrine cells in the intestinal lining, potentially stimulating endogenous GLP-1 release