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However, the evidence in humans remains preliminary and inconclusive, and neither EFSA nor the FSA has issued guidance restricting their use on this basis

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16, 2025 from Rubino, D., Abrahamsson, N., Davies, M., et al (2021)

It is important to note that while GLP-1RAs have demonstrated CV safety, not all result in an actual reduction in CV adverse events, such as exenatide QW and lixisenatide, both of which were reported to be non-inferior to placebo for MACE [22, 23]

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In 2021, AMG133, a bispecific molecule that combines GIP receptor antagonism and GLP-1 receptor agonism was presented