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Physiological levels of ROS are essential for sustaining T cell receptor (TCR) signaling, glycolytic reprogramming, and cytotoxic activity, while excessive or prolonged oxidative stress drives exhaustion and apoptosis
Anti-tumor activity:DSIP also has anti-tumor effects
doi:10.1056/NEJMoa2023184 16
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These changes were accompanied by elevated nitric oxide production and aberrant expression of angiogenesis-related genes, including VEGFA, HIF-1, eNOS, iNOS, FGF-2, and ANG1
Chirinos, J
