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In wounded tissue, nociceptive signaling is not merely a consequence of direct activation of peripheral nerves by trauma but arises from a dynamic interplay between immune, inflammatory, and neural components of the tissue microenvironment
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You do not need to inject directly at the injury site, though some users prefer to do so

The gut commensal Bacteroides thetaiotaomicron exacerbates enteric infection through modification of the metabolic landscape