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When that layer takes on oxidative damage, a lot of things downstream start to suffer
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Glodde N, Bald T, van den Boorn-Konijnenberg D, Nakamura K, ODonnell JS, Szczepanski S, Brandes M, Eickhoff S, Das I, Shridhar N, et al

This physiological mechanism, which is useful for the post-translational modification of multiple proteins and for the regulation of signal and metabolic pathways, can turn harmful in case of oxidative stress, with the above-mentioned mitochondrial damage

Glutamine catabolism in vivo As mentioned above, the ability of some tumors to synthesize glutamine de novo to meet biosynthetic needs suggests that exogenous glutamine may not be required by all proliferating cells in vivo

and showed that EV-derived alpha-synuclein was able to discriminate PD from controls (AUC 0.77) and had an inverse relationship with motor severity 108
