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Alteration of several metabolic enzymes and pathways that affect KG abundance and KGDD activity have been reported in cancer, such as mutations of the genes encoding isocitrate dehydrogenase 1 and 2 (IDH1 and IDH2), changes in glutaminolysis that deplete KG, and alterations in fumarate hydratase and succinate dehydrogenase that inhibit KGDD activity 11

OptimalDose of Aerobic Exercise Programs to Reduce Pain Intensity and ImproveHealth Status in Patients With Fibromyalgia: A Dose-Response Meta-Analysis

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demonstrated that hypoxia at high altitude causes adverse effects on sperm quality and reproductive hormones, and these effects are reversible [47]