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For adults with type 2 diabetes and established atherosclerotic cardiovascular disease, high cardiovascular risk, chronic kidney disease, or heart failure, guidelines recommend GLP-1 agonists with proven cardiovascular benefit as preferred agents, independent of metformin use or baseline A1C

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Most cases improve over time due to tachyphylaxis, where the body adapts to the medication's effects

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[DOI] [PubMed] [Google Scholar] 3.van Raalte DH, et al

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