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Many clinical trials check whether the effect at the cellular level translates into an improvement in the clinical condition of patients

The early data from obesity trials shows favorable trends in cardiovascular risk factors, but definitive outcome data remains forthcoming

To view or add a comment, sign in Drug of the day Rilzabrutinib is a drug that acts as a Brutons tyrosine kinase (BTK) inhibitor

When multiple lines of evidence point in the same physiological direction, negative translational outcomes should be scrutinized for methodological rather than biological causes

doi: 10.3389/fcdhc.2025.1720794 Received 09 October 2025 Accepted 03 November 2025 Published 24 November 2025 Volume 6 - 2025 Edited by Marilena Vitale, Federico II University Hospital, Italy Reviewed by Theodoros Androutsakos, National and Kapodistrian University of Athens, Greece Gianpaolo Zerbini, San Raffaele Hospital (IRCCS), Italy Giovanna DAbbronzo, Federico II University Hospital, Italy Updates Copyright 2025 Codella, Senesi and Luzi