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The magnitude varies significantly between individuals: STEP 4 Trial : Participants who stopped semaglutide after 20 weeks regained approximately 7% body weight over next 48 weeks (compared to losing an additional 8% who continued medication) Real-World Studies : Variable outcomes

Roche announced today positive topline results from two arms of an ongoing multi-part Phase I clinical trial for CT-996, an investigational, once-daily, oral small molecule GLP-1 receptor agonist being developed for the treatment of both type 2 diabetes and obesity

2 (download XLSX Statistical source data for Extended Data Fig

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A lot of insurance companies do not cover anti-obesity medication