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The inclusion of glucagon agonism was initially counterintuitive, but research suggests that when combined with GLP-1 and GIP activity, the net metabolic effect may be beneficial rather than hyperglycemic

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Eli Lilly , the manufacturer, does not provide guidance on combining multiple tirzepatide injections, as it has not been studied in clinical trials

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Additionally, Mounjaro , one of the newer diabetes drugs, which was approved in May 2022 and has a unique dual mechanism of action (it activates the GLP-1 hormone as well as another hormone called the glucose-dependent insulinotropic polypeptide or GIP, both helping to improve blood sugar) may be even more effective than semaglutide in reducing weight

The mindless calories, the second helping you did not need, the late-night grazing, are exactly the calories that turn a clean surplus into a fat-gaining one