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These effects require consistent receptor activation above a threshold that typically corresponds to 1.0 mg or higher weekly doses

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Discontinuation before conception, guided by each drugs pharmacokinetic profile, remains prudent to minimize potential fetal exposure: approximately 35 days for semaglutide (t 7 days), 2535 days for tirzepatide (t 5 days), and 3 days for liraglutide (t 13 h)