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In our study, we also reported that REE decreased at M7, reflecting the expected metabolic adaptation to weight loss, 22 but increased significantly at M12 when normalised to lean mass

According to Sadaf Javed, an endocrinology and metabolic disorders expert at DelveInsight, Eli Lilly is currently positioned as the frontrunner in the GLP-1-based obesity market, supported by its clinical differentiation, robust intellectual property protection, and expanding commercial reach

This represents a significant advantage over leptin-based therapies and partly explains the clinical success of GLP-1 receptor agonists in weight management

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