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Description
The authors suggest this may be because most patients in their study were using GLP-1 RAs to manage diabetes rather than obesity, and because cancer treatments such as chemotherapy, steroids, and endocrine therapy can reduce the drugs weight-loss effects

Semaglutide is a GLP-1 receptor agonist that primarily acts on receptors in the brain (appetite regulation), pancreas (insulin secretion), and gastrointestinal tract (gastric emptying)

Consequently, patients with T2DM often exhibit reduced Pdx1 expression levels (Ofori et al., 2022)

The body composition changes they produce are similar to what happens with any significant weight loss

Neither drug manufacturer commented on the lawsuit specifically, but they emphasized the differences between their products

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