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The GLP-1RA exenatide has been shown to reduce hyperactivation in brain regions associated with appetite and reward in response to food cues in both obese individuals with type 2 diabetes and obese normoglycemic subjects, thereby normalizing neural activation patterns to resemble those observed in lean individuals [48]

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Heterogeneity between subgroups was formally tested using interaction terms

Exenatide once weekly versus placebo in Parkinson's disease: A randomised, double-blind, placebo-controlled trial