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A practical approach includes regular assessment of liver enzymes and metabolic parameters during treatment
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Although the residues at the N-terminal position may have a major impact by inhibiting DPP4, the authors pointed out that the C-terminal amino acid also affects the potency of DPP4 because it is involved in the interaction with the enzyme (Reference Lan, Ito and Ohno95)
B 15 , 1534 (2025)
