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Effect of vitamin B12 on the sleep-wake rhythm following an 8-hour advance of the light-dark cycle in the rat

Guzmn-RuizRTercero-AlczarCLpez-AlcalJSnchez-CeinosJMalagnMMGordonA

Oxidative stress results when reactive forms of oxygen are produced faster than they can be safely neutralized by antioxidant mechanisms and/or from a decrease in antioxidant defense, which may lead to damage of biological macromolecules and disruption of normal metabolism and physiology [5]

Data availability The datasets analyzed during the current study are not publicly available as it is meant to be published as Meta data sharing may publicise long term aim of this research however, data can be available from the corresponding author on reasonable request

As experimental evidence regarding putative candidate nutrients in animal models of epilepsy [214,215,216,217] is readily available, it will be necessary to examine the translational potential of these molecules to facilitate the development of nutraceuticals for epilepsy treatment

Quadrilatero J, Hoffman-Goetz L: N-Acetyl-L-cysteine prevents exercise-induced intestinal lymphocyte apoptosis by maintaining intracellular glutathione levels and reducing mitochondrial membrane depolarization